Endocrine Abstracts

Introduction: The circadian clock controls numerous aspects of mammalian physiology across the 24 hour day, including lipid and glucose metabolism. Disruption of the core circadian gene CLOCK is associated with the development of obesity, diabetes and the metabolic syndrome in mice. Women with Polycystic Ovary Syndrome (PCOS) are at increased risk of developing diabetes, dyslipidemia and the metabolic syndrome. The aim of the present study was to investigate the relationship o...

Introduction: The circadian clock controls numerous aspects of mammalian physiology across the 24 hour day. The suprachiasmatic nucleus (SCN) is the “master clock” which coordinates the peripheral clocks in the body, including the pineal clock that receives SCN input via a multisynaptic noradrenergic pathway. Murine studies have shown a role for the core clock gene BMAL1 in the regulation of blood pressure. Selected haplotypes of BMAL1 have previously been associated...